The association between the laryngeal saccule and a laryngocele is an important clinical relationship. Here, we describe this and other clinical correlations of the saccule including infection and carcinoma and suggest that these should be discussed in medical gross anatomy courses. We also briefly present some descriptive information on the anatomy and function of the saccule in humans and other higher primates. Clin. Anat. 25:647–649, 2012. © 2011 Wiley Periodicals, Inc.