MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma (pages 141–155)
Wiyada Kwanhian, Dido Lenze, Julia Alles, Natalie Motsch, Stephanie Barth, Celina Döll, Jochen Imig, Michael Hummel, Marianne Tinguely, Pankaj Trivedi, Viraphong Lulitanond, Gunter Meister, Christoph Renner and Friedrich A. Grässer
Article first published online: 18 SEP 2012 | DOI: 10.1002/cam4.29
The precursor or the mature microRNA miR-142-3p or miR-142-5p was found to be mutated in 20% of diffuse large B-cell lymphoma (DLBCL). Some of the mutations were found to abrogate the function of the microRNA vis-a-vis known targets. We hypothesize that loss-of-function mutations in miR-142 might contribute to the induction or maintenance of DLBCL.