Individual transcriptional activity of estrogen receptors in primary breast cancer and its clinical significance (pages 328–337)
Tatsuyuki Gohno, Yuko Seino, Toru Hanamura, Toshifumi Niwa, Mitsuyo Matsumoto, Nobuo Yaegashi, Hanako Oba, Masafumi Kurosumi, Hiroyuki Takei, Yuri Yamaguchi and Shin-ichi Hayashi
Article first published online: 30 OCT 2012 | DOI: 10.1002/cam4.41
We established a novel method for analyzing ERE transcriptional activity in clinical specimens, and observed varying ERE activity and drug sensitivity in individual samples. Notably, ER protein expression and ERE transcriptional activity were not always correlated. Our method could help analysis of individual cases and their likely response to hormone-based therapy.