Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases (pages 76–85)
Heike Niessner, Andrea Forschner, Bernhard Klumpp, Jürgen B. Honegger, Maria Witte, Antje Bornemann, Reinhard Dummer, Annemarie Adam, Jürgen Bauer, Ghazaleh Tabatabai, Keith Flaherty, Tobias Sinnberg, Daniela Beck, Ulrike Leiter, Cornelia Mauch, Alexander Roesch, Benjamin Weide, Thomas Eigentler, Dirk Schadendorf, Claus Garbe, Dagmar Kulms, Leticia Quintanilla-Martinez and Friedegund Meier
Version of Record online: 12 DEC 2012 | DOI: 10.1002/cam4.50
In patients with metastatic melanoma, brain metastases are the most common cause of death. Our findings suggest that hyperactivation of the AKT survival pathway in melanoma brain metastases promotes the survival and drug resistance of melanoma cells in the brain parenchyma. Inhibition of this pathway thus has potential as a novel strategy for the treatment of melanoma brain metastases.