Identification of multiple subclones in peripheral T-cell lymphoma, not otherwise specified with genomic aberrations
Version of Record online: 25 SEP 2012
© 2012 The Authors. Cancer Medicine published by Blackwell Publishing Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 1, Issue 3, pages 289–294, December 2012
How to Cite
Cancer Medicine 2012; 1(3): 289-294
- Issue online: 3 DEC 2012
- Version of Record online: 25 SEP 2012
- Manuscript Accepted: 27 AUG 2012
- Manuscript Revised: 27 JUL 2012
- Manuscript Received: 22 JUN 2012
- Ministry of Health and Welfare
- The Ministry of Education, Culture, Sports, Science, and Technology
- Japan Society for the Promotion of Science
- Multiple subclones, not otherwise specified;
- oligo-array comparative genomic hybridization;
- peripheral T-cell lymphoma
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with genomic aberrations has been shown to resemble lymphoma-type adult T-cell leukemia/lymphoma (ATLL) in terms of its genomic aberration patterns, histopathology, and prognosis. We have shown recently that a majority of patients with acute-type ATLL have multiple subclones that were likely produced in lymph nodes. In this study, we analyzed whether PTCL, NOS with genomic aberrations also has multiple subclones as found in ATLL by means of high-resolution oligo-array comparative genomic hybridization (CGH). Thirteen cases of PTCL, NOS were available for 44K high-resolution array CGH analysis. The results showed that 11 (84.6%) of the 13 cases had a log2 ratio imbalance, suggesting that multiple subclones exist in PTCL, NOS with genomic aberrations. In order to analyze the association between multiple subclones and prognosis, we used previous bacterial-artificial chromosome (BAC) array analyses for 29 cases and found that the existence of multiple subclones was associated with a poor prognosis (P = 0.0279).