1st Communication: .
Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides. 2nd Communication†
Derivation and Reactivity of Xylose Phosphates
Article first published online: 21 OCT 2004
Copyright © 2004 Verlag Helvetica Chimica Acta AG, Zürich
Chemistry & Biodiversity
Volume 1, Issue 10, pages 1418–1451, October 2004
How to Cite
Smith, James M., Borsenberger, V., Raftery, J. and Sutherland, John D. (2004), Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides. 2nd Communication. Chemistry & Biodiversity, 1: 1418–1451. doi: 10.1002/cbdv.200490105
- Issue published online: 21 OCT 2004
- Article first published online: 21 OCT 2004
- Manuscript Received: 25 MAY 2004
The potentially prebiotic synthesis of ribo-nucleotides by stepwise pyrimidine nucleobase assembly on arabinose-3-phosphate derivatives has been demonstrated in previous work . Consideration of the provenance of pentose phosphates, by aldolisation or sugar phosphorylation, suggested that 2-phosphate derivatives might be generated more easily than 3-phosphate derivatives. In the 2-phosphate series, nucleobase-assembly chemistry to give ribo-nucleotides/nucleic acid can be envisaged from xylo-configured starting materials. In this paper, the derivation of xylose-2-phosphate derivatives by aldol chemistry and attempts to demonstrate subsequent pyrimidine nucleobase assembly are reported.