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Research Article

Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain-Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction

  1. Zhen-Dan Shi1,
  2. Rajeshri G. Karki1,
  3. Karen M. Worthy2,
  4. Lakshman K. Bindu2,
  5. Marc C. Nicklaus1,
  6. Robert J. Fisher2,
  7. Terrence R. Burke Jr.1

Article first published online: 18 APR 2005

DOI: 10.1002/cbdv.200590024

Issue

Chemistry & Biodiversity

Chemistry & Biodiversity

Volume 2, Issue 4, pages 447–456, April 2005

Additional Information

How to Cite

Shi, Z.-D., Karki, Rajeshri G., Worthy, Karen M., Bindu, Lakshman K., Nicklaus, Marc C., Fisher, Robert J. and Burke, Terrence R. (2005), Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain-Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction. Chemistry & Biodiversity, 2: 447–456. doi: 10.1002/cbdv.200590024

Author Information

  1. 1

    Laboratory of Medicinal Chemistry, CCR, NCI, NIH, P.O. Box B, Bldg 376 Boyles St., Frederick, MD 21702-1201, USA (phone: +1 301-846-5906; fax: +1-301-846-6033)

  2. 2

    Protein Chemistry Laboratory, SAIC-Frederick, Frederick, MD 21702-1201, USA.

Publication History

  1. Issue published online: 18 APR 2005
  2. Article first published online: 18 APR 2005
  3. Manuscript Received: 10 DEC 2004

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  1. 1
    Dziyana Kraskouskaya, Eugenia Duodu, Carolynn C. Arpin, Patrick T. Gunning, Progress towards the development of SH2 domain inhibitors, Chemical Society Reviews, 2013, 42, 8, 3337

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  2. 2
    Fa Liu, Karen M. Worthy, Lakshman Bindu, Alessio Giubellino, Donald P. Bottaro, Robert J. Fisher, Terrence R. Burke Jr., Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis, Organic & Biomolecular Chemistry, 2007, 5, 2, 367

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    Won Jun Choi, Zhen-Dan Shi, Karen M. Worthy, Lakshman Bindu, Rajeshri G. Karki, Marc C. Nicklaus, Robert J. Fisher, Terrence R. Burke, Application of azide–alkyne cycloaddition ‘click chemistry’ for the synthesis of Grb2 SH2 domain-binding macrocycles, Bioorganic & Medicinal Chemistry Letters, 2006, 16, 20, 5265

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    Terrence R. Burke, Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents, International Journal of Peptide Research and Therapeutics, 2006, 12, 1, 33

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    Rebecca L. Rich, David G. Myszka, Survey of the year 2005 commercial optical biosensor literature, Journal of Molecular Recognition, 2006, 19, 6
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