On leave from Department of Chemistry, Faculty of Science, El-Menoufia University, El-Kom, El-Menoufia, Egypt.
Aryl Ketones from Acronychia pedunculata with Cyclooxygenase-2 Inhibitory Effects
Article first published online: 18 APR 2005
Copyright © 2005 Verlag Helvetica Chimica Acta AG, Zürich
Chemistry & Biodiversity
Volume 2, Issue 4, pages 463–469, April 2005
How to Cite
Pathmasiri, W., El-Seedi, Hesham R., Han, X., Janson, J.-C., Huss, U. and Bohlin, L. (2005), Aryl Ketones from Acronychia pedunculata with Cyclooxygenase-2 Inhibitory Effects. Chemistry & Biodiversity, 2: 463–469. doi: 10.1002/cbdv.200590026
- Issue published online: 18 APR 2005
- Article first published online: 18 APR 2005
- Manuscript Received: 17 NOV 2004
1-[2,4-Dihydroxy-6-methoxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl]ethanone (1), and a new aryl ketone, named acrovestenol (2), were isolated as cyclooxygenase-2 (COX-2) inhibitory principles from a CH2Cl2 extract of the bark of Acronychia pedunculata by a bioassay-guided fractionation procedure. Compound 2 inhibited COX-2 with an IC50 value of 142.0±2.15 μM, compared to the COX-2 inhibitory reference compound NS-398 with an IC50 value of 11.3±1.12 μM. Compound 1 inhibited COX-2-catalyzed PG biosynthesis with 68% at a concentration of 500 μM. The structures were determined by UV, IR, and 1D- and 2D-NMR, including TOCSY, HSQC-DEPT, and HMBC, and MS investigations.