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H. R. thanks the Francqui Foundation for a senior postdoctoral fellowship and Prof. Dr. Piet Herdewijn, Rega Institute, KU Leuven, for hosting a stay at the Department for Medicinale Chemie.
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Review
Nucleolipids: Natural Occurrence, Synthesis, Molecular Recognition, and Supramolecular Assemblies as Potential Precursors of Life and Bioorganic Materials†
Article first published online: 23 AUG 2005
DOI: 10.1002/cbdv.200590082
Copyright © 2005 Verlag Helvetica Chimica Acta AG, Zürich
Additional Information
How to Cite
Rosemeyer, H. (2005), Nucleolipids: Natural Occurrence, Synthesis, Molecular Recognition, and Supramolecular Assemblies as Potential Precursors of Life and Bioorganic Materials. Chemistry & Biodiversity, 2: 977–1063. doi: 10.1002/cbdv.200590082
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Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Manuscript Received: 25 MAR 2005
- Abstract
- References
- Cited By
Abstract
Nucleolipids are hybrid molecules composed of a nucleobase, a nucleoside, a nucleotide or an oligonucleotide (either DNA or RNA), and a lipophilic moiety, which might be either simply a single- or double-chained alkyl (or alkenyl) moiety or a carbocyclic hydrocarbon such as cholesterol, a vitamin, or a bile acid. This review covers all aspects of nucleolipids, namely their natural occurrence, their synthesis, their molecular recognition, as well as aggregation behavior, either in aqueous or non-aqueous solution. Potential future aspects of nucleolipids in material sciences and for the elucidation of biochemical reactions in living cells are discussed.