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Keywords:

  • Resveratrol derivatives;
  • Anticancer activity;
  • Cytotoxic activity;
  • Structure–activity relationships (SAR)

Abstract

A total of 17 resveratrol (=(E)-5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) derivatives were synthesized from resveratrol (RES) through a facile approach. Among them, 13 compounds, 2 and 617, were reported for the first time, while 1 and 35 had already been reported several years ago. The cytotoxic activities of these compounds were evaluated against human nasopharyngeal epidermoid tumor cell line KB, and compounds 1 and 811 showed strong anticancer activities in vitro, comparable with that of 5-fluorouracil, an anticancer drug. On the basis of the experimental data obtained, structure–activity relationships are discussed.