SEARCH

SEARCH BY CITATION

Keywords:

  • Copper complexes;
  • Hydrazones;
  • Tetradentate ligands;
  • DNA

Abstract

Three hydrazone ligands, H2L1H2L3, made from salicylaldehyde and ibuprofen- or naproxen-derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [CuIIL1]⋅H2O, [CuIIL2], and [(CuII)2(L3)2]⋅H2O⋅DMF (Scheme). The X-ray crystal structure of the last-mentioned complex was solved (Fig. 1), showing a square-planar complexation geometry, and the single units were found to form a one-dimensional chain structure (Fig. 2). The interactions of these complexes with CT-DNA were studied by different techniques, indicating that they all bind to DNA by classical and/or non-classical intercalation modes.