Arguside A: A New Cytotoxic Triterpene Glycoside from the Sea Cucumber Bohadschia argusJaeger

Authors

  • Bao-Shu Liu,

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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  • Yang-Hua Yi,

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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  • Ling Li,

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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  • Shi-Long Zhang,

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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  • Hua Han,

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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  • Yi-Yi Weng,

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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  • Min-Xiang Pan

    1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, 200433 Shanghai, P. R. China, (phone: +86-21-65384988; fax: +86-21-65483662)
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Abstract

A new holostane-based triterpene glycoside, arguside A (1), was isolated from the sea cucumber Bohadschia argus, collected in the South China Sea. The structure of the new compound was elucidated by spectroscopic and mass-spectrometric analyses, in combination with chemical transformations. Compound 1 exhibited significant cytotoxicity against different human tumor cell lines, being more active towards HCT-116 cells (IC50=0.14 μM) than 10-hydroxycamptothecin (HCP) used as positive control.

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