Incarviditone: A Novel Cytotoxic Benzofuranone Dimer from Incarvillea delavayiBureau et Franchet

Authors

  • Yu-Qi Chen,

    1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China (phone: +86-21-25070386; fax: +86-21-25070386)
    2. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China
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  • Yun-Heng Shen,

    1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China (phone: +86-21-25070386; fax: +86-21-25070386)
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  • Yong-Qing Su,

    1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China (phone: +86-21-25070386; fax: +86-21-25070386)
    2. No. 123rd Hospital of People's Liberation Army of China, Anhui 233015, P. R. China
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  • Ling-Yi Kong,

    1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China
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  • Wei-Dong Zhang

    1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China (phone: +86-21-25070386; fax: +86-21-25070386)
    2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, P. R. China
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Abstract

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A novel benzofuranone dimer, named incarviditone (1), along with known rengyolone (2), was isolated from Incarvillea delavayiBureau et Franchet. The structure of the new compound was elucidated on the basis of spectroscopic methods, especially 2D-NMR and MS analyses. Compound 1 is the first example of a benzofuranone dimer connected by a C[BOND]C bond, which presents a new C-skeleton. The cytotoxicities of compounds 1 and 2 were evaluated against the cell lines A549, LOVO, HL-60, 6T-CEM, and HepG2. Incarviditone (1) exhibited cytotoxicity only against HL-60 and 6T-CEM cell lines with IC50 values of 14.8 and 22.2 μg/ml, respectively, while rengyolone (2) was more active against all cell lines with IC50 values between 6.7 and 20.2 μg/ml.

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