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Research Article
New Isoprenylated 2-Arylbenzofurans and Pancreatic Lipase Inhibitory Constituents from Artocarpus nitidus
Article first published online: 17 DEC 2009
DOI: 10.1002/cbdv.200900130
Copyright © 2009 Verlag Helvetica Chimica Acta AG, Zürich
1612-1880/asset/cover.gif?v=1&s=cc68b12e733d21d6415eeec10551f83cb03996eb "Chemistry & Biodiversity")
Additional Information
How to Cite
Zhao, T., Yan, G.-R., Pan, S.-L., Wang, H.-Y. and Hou, A.-J. (2009), New Isoprenylated 2-Arylbenzofurans and Pancreatic Lipase Inhibitory Constituents from Artocarpus nitidus. Chemistry & Biodiversity, 6: 2209–2216. doi: 10.1002/cbdv.200900130
Publication History
- Issue published online: 17 DEC 2009
- Article first published online: 17 DEC 2009
- Manuscript Received: 17 FEB 2009
- Abstract
- References
- Cited By
Keywords:
- Artocarpus nitidus;
- Arylbenzofurans;
- Inhibitors;
- Artonitidins A and B;
- Pancreatic lipase
Abstract
Two new isoprenylated 2-arylbenzofurans, artonitidin A (=(2′R)-2′,3′-dihydro-2′-(1-hydroxy-1-methylethyl)-5′,7-bis(3-methylbut-2-en-1-yl)-2,4′-bi-1-benzofuran-6,6′-diol; 1) and artonitidin B (=5-[6-hydroxy-7-(3-methylbut-2-en-1-yl)-1-benzofuran-2-yl]-4-(3-methylbut-2-en-1-yl)benzene-1,3-diol; 2), together with 14 known compounds, 3–16, were isolated from the stems of Artocarpus nitidusTrec. The structures were elucidated by spectroscopic methods. Norartocarpin (3), cudraflavone C (5), brosimone I (8), artotonkin (11), albanin A (13), and artopetelin M (14) showed inhibitory effects on pancreatic lipase with IC50 values ranging from 1.8±0.1 to 63.8±3.6 μM.