Research Article

Bioactive Triterpenoids from Kadsura heteroclita

  1. Li-Jia Xu1,
  2. Zong-Gen Peng2,
  3. Hong-Shan Chen2,
  4. Jie Wang3,
  5. Pei-Gen Xiao1

Article first published online: 16 SEP 2010

DOI: 10.1002/cbdv.200900173

Issue

Chemistry & Biodiversity

Chemistry & Biodiversity

Volume 7, Issue 9, pages 2289–2295, September 2010

Additional Information

How to Cite

Xu, L.-J., Peng, Z.-G., Chen, H.-S., Wang, J. and Xiao, P.-G. (2010), Bioactive Triterpenoids from Kadsura heteroclita. Chemistry & Biodiversity, 7: 2289–2295. doi: 10.1002/cbdv.200900173

Author Information

  1. 1

    Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, NO. 151 Malianwa North Road, Haidian District, Beijing 100094, P. R. China, (phone: +86-10-63011294; fax: +86-10-62899714)

  2. 2

    Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, P. R. China

  3. 3

    Guang'anmen Hospital, China Academy of Chinese Medical Science, Beijing 100053, P. R. China

Publication History

  1. Issue published online: 16 SEP 2010
  2. Article first published online: 16 SEP 2010
  3. Manuscript Received: 15 MAY 2009

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Keywords:

  • Kadsura heteroclita;
  • Triterpenoids;
  • HIV-I Protease inhibition;
  • Cytotoxic activity;
  • Anti-HIV activity

Abstract

A phytochemical study of Kadsura heteroclita led to the isolation of eight triterpenoids, including two new compounds, named kadheterilactone A (1) and kadheterilactone B (2), as well as six known compounds, longipedlactone H (3), longipedlactone A (4), longipedlactone F (5), kadsuranic acid A (6), nigranoic acid (7), and schisandronic acid (8). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. The cytotoxic activities of 1–8 were tested against several tumor cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide (MTT) assay in vitro. As a result, 4 and 5 turned out to be significantly cytotoxic against Hep-G2 and Bel-7402 tumor cell lines. All compounds were also tested for inhibition on HIV-1 protease (PR) and reverse transcriptase (RT). Compounds 6 and 7 showed strong inhibition on HIV-1 PR, while 8 exhibited moderate activity, others were only weakly active. No compounds were active against HIV-1 RT.

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