The Resurgence of Acyclic Nucleic Acids

Authors

  • Su Zhang,

    1. Center for Evolutionary Functional Genomics, The Biodesign Institute, and Department of Chemistry and Biochemistry at Arizona State University, Tempe, Arizona 85287-5301, USA, (phone: (480)727-0392)
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  • Christopher Switzer,

    1. Department of Chemistry, University of California, Riverside, California 92521, USA, (phone: (951)827-7266)
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  • John C. Chaput

    1. Center for Evolutionary Functional Genomics, The Biodesign Institute, and Department of Chemistry and Biochemistry at Arizona State University, Tempe, Arizona 85287-5301, USA, (phone: (480)727-0392)
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Abstract

This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic-acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self-assembly.

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