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Haemolytic Activity and Immunological Adjuvant Effect of a New Steroidal Saponin from Allium ampeloprasum var. porrum

  1. Camila Rodrigues Adão,
  2. Bernadete Pereira da Silva,
  3. Luzineide Wanderley Tinoco,
  4. José Paz Parente*

Article first published online: 17 JAN 2012

DOI: 10.1002/cbdv.201100005

Issue

Chemistry & Biodiversity

Chemistry & Biodiversity

Volume 9, Issue 1, pages 58–67, January 2012

Additional Information

How to Cite

Adão, C. R., Pereira da Silva, B., Tinoco, L. W. and Parente, J. P. (2012), Haemolytic Activity and Immunological Adjuvant Effect of a New Steroidal Saponin from Allium ampeloprasum var. porrum. Chemistry & Biodiversity, 9: 58–67. doi: 10.1002/cbdv.201100005

Author Information

  1. Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Caixa Postal 68045, CEP 21941-971 Rio de Janeiro, Brazil, (phone: +552125626791; fax: +552122702683)

*Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Caixa Postal 68045, CEP 21941-971 Rio de Janeiro, Brazil, (phone: +552125626791; fax: +552122702683)

Publication History

  1. Issue published online: 17 JAN 2012
  2. Article first published online: 17 JAN 2012
  3. Manuscript Received: 5 JAN 2011

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Keywords:

  • Allium ampeloprasum var. porrum;
  • Steroids;
  • Saponins;
  • Haemolytic activity;
  • Immunological adjuvants

Abstract

A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum L. var. porrum. On the basis of chemical evidence, comprehensive spectroscopic analyses, and comparison with known compounds, its structure was established as (3β,5α,6β,25R)-3-{(O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2)-O-[O-β-D-glucopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy}-6-hydroxyspirostan-2-one (1). Results of the present study indicated that 1 exhibited haemolytic activity in the in vitro assays, and immunological adjuvant activity on the cellular immune response against ovalbumin antigen.

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