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Synthesis and Antidiabetic Activity of 5,7-Dihydroxyflavonoids and Analogs

  1. Liu-Shuan Chang1,
  2. Chun-Bao Li2,
  3. Nan Qin1,
  4. Mei-Na Jin1,
  5. Hong-Quan Duan1,*

Article first published online: 17 JAN 2012

DOI: 10.1002/cbdv.201100049

Issue

Chemistry & Biodiversity

Chemistry & Biodiversity

Volume 9, Issue 1, pages 162–169, January 2012

Additional Information

How to Cite

Chang, L.-S., Li, C.-B., Qin, N., Jin, M.-N. and Duan, H.-Q. (2012), Synthesis and Antidiabetic Activity of 5,7-Dihydroxyflavonoids and Analogs. Chemistry & Biodiversity, 9: 162–169. doi: 10.1002/cbdv.201100049

Author Information

  1. 1

    School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P. R. China, (phone: +86-22-23542018; fax: +86-22-23542775)

  2. 2

    School of Science, Tianjin University, Tianjin 300072, P. R. China, (phone: +86-22-27892351; fax: +86-22-27403475)

*School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P. R. China, (phone: +86-22-23542018; fax: +86-22-23542775)

Publication History

  1. Issue published online: 17 JAN 2012
  2. Article first published online: 17 JAN 2012
  3. Manuscript Received: 11 FEB 2011

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Keywords:

  • Flavonoids, 5,7-dihydroxy-;
  • Antidiabetic activity

Abstract

In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5,7-dihydroxyflavanones and 5,7-dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d, and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7-dihydroxyflavonoids can be considered as promising candidates in the development of new antidiabetic lead compounds.

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