M.-D. W. and M.-J. C. contributed equally to this work and are co-first authors.
Inhibitory Effects of Maleimide Derivatives from the Mycelia of the Fungus Antrodia cinnamomea BCRC 36799 on Nitric Oxide Production in Lipopolysaccharide (LPS)-Activated RAW264.7 Macrophages
Article first published online: 13 MAR 2013
Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich
Chemistry & Biodiversity
Volume 10, Issue 3, pages 434–441, March 2013
How to Cite
Wu, M.-D., Cheng, M.-J., Yech, Y.-J., Yuan, G.-F. and Chen, J.-J. (2013), Inhibitory Effects of Maleimide Derivatives from the Mycelia of the Fungus Antrodia cinnamomea BCRC 36799 on Nitric Oxide Production in Lipopolysaccharide (LPS)-Activated RAW264.7 Macrophages. Chemistry & Biodiversity, 10: 434–441. doi: 10.1002/cbdv.201200258
- Issue published online: 13 MAR 2013
- Article first published online: 13 MAR 2013
- Manuscript Received: 24 JUL 2012
- Antrodia cinnamomea BCRC 36799;
- Maleimide derivatives;
- Antrocinnamomins E – H;
- Nitric oxide production;
Four new maleimide derivatives, antrocinnamomins E–H (1–4, resp.), together with (3S,4R)-1-hydroxy-3-(4-hydroxyphenyl)-4-(2-methylpropyl)pyrrolidine-2,5-dione (5) and ergosterol were isolated from the mycelia of Antrodia cinnamomea BCRC 36799. The structures were elucidated by 1D- and 2D-NMR spectroscopy, and mass spectrometry. Compounds 1–5 were evaluated for their inhibitory effects on nitric oxide (NO) production by macrophages. Compounds 2 and 4 showed stronger inhibition of NO production than the positive control quercetin.