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Keywords:

  • Dipeptides;
  • Peptides;
  • DNA;
  • Polymerases;
  • Nucleotides

Abstract

Conjugates of 2′-deoxyadenosine monophosphate with dipeptides have been synthesized and tested as substrates for several polymerases. Although the incorporation efficiency is not very high, it demonstrates that some of these dipeptides can be accommodated in the active site of polymerases and function as leaving groups in the enzymatic synthesis of DNA.