These authors contributed equally to this work.
Acetylcholinesterase-Inhibitory Activities of the Extracts from Sponges Collected in Mauritius Waters
Article first published online: 13 MAR 2013
Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich
Chemistry & Biodiversity
Volume 10, Issue 3, pages 442–451, March 2013
How to Cite
Beedessee, G., Ramanjooloo, A., Surnam-Boodhun, R., van Soest, R. W. M. and Marie, D. E. P. (2013), Acetylcholinesterase-Inhibitory Activities of the Extracts from Sponges Collected in Mauritius Waters. Chemistry & Biodiversity, 10: 442–451. doi: 10.1002/cbdv.201200343
- Issue published online: 13 MAR 2013
- Article first published online: 13 MAR 2013
- Manuscript Received: 9 OCT 2012
- Alzheimer's disease
Patients diagnosed with Alzheimer's disease (AD) show a characteristic neurochemical deficit of acetylcholine, especially in the basal forebrains. The use of acetylcholinesterase (AChE) inhibitors to retard the hydrolysis of acetylcholine has been suggested as a promising strategy for AD treatment. In this study, we evaluated the acetylcholinesterase inhibitory (AChEI) activities of 134 extracts obtained from 45 species of marine sponges. Thin-layer chromatography (TLC) and microplate assays reveal potent acetylcholinsterase inhibitory activities of two AcOEt extracts from the sponges Pericharax heteroraphis and Amphimedon navalis Pulitzer-Finali. We further investigated the inhibitory kinetics of the extracts and found them to display mixed competitive/noncompetitive inhibition and associated their inhibitory activity partly to terpenoids. Acetylcholinesterase inhibitors from marine organisms have been rarely studied, and this study demonstrated the potential of marine sponges as a source of pharmaceutical leads against neurodegenerative diseases.