Phytochemical Investigation of Annulohypoxylon ilanense, an Endophytic Fungus Derived from Cinnamomum Species

Authors

  • Ming-Der Wu,

    1. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886-3-522-3191 ext 585)
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  • Ming-Jen Cheng,

    Corresponding author
    1. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886-3-522-3191 ext 585)
    • Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886-3-522-3191 ext 585)
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    • Corresponding author for chemical aspects and manuscript.

    • Corresponding authors for general information.

    • First co-author.

  • Ih-Sheng Chen,

    Corresponding author
    1. College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan
    • College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan
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    • Corresponding author for taxonomic information.

  • Yung-Shun Su,

    1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan
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  • Sung-Yuan Hsieh,

    1. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886-3-522-3191 ext 585)
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  • Hsun-Shuo Chang,

    1. College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan
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  • Chun-Wei Chang,

    1. College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan
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  • Gwo-Fang Yuan

    Corresponding author
    1. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886-3-522-3191 ext 585)
    • Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886-3-522-3191 ext 585)
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    • Corresponding authors for general information.


Abstract

Cultivation of the fungal strain Annulohypoxylon ilanense, an endophytic fungus isolated from the wood of medicinal plant Cinnamomum species, resulted in the isolation of one new furanoid derivative, ilanefuranone (1), one new pyrrole alkaloid, ilanepyrrolal (2), and one new biarylpropanoid derivative, ilanenoid (3), together with 22 known compounds, of which one α-tetralone analog, (−)-(4R)-3,4-dihydro-4,6-dihydroxynaphthalen-1(2H)-one (4) was isolated for the first time from a natural source. The structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, and high-resolution mass spectrometry, and the antimycobacterial activities were also evaluated.

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