The role of glutathione in cancer
Article first published online: 11 AUG 2004
Copyright © 2004 John Wiley & Sons, Ltd.
Cell Biochemistry and Function
Volume 22, Issue 6, pages 343–352, November/December 2004
How to Cite
Balendiran, G. K., Dabur, R. and Fraser, D. (2004), The role of glutathione in cancer. Cell Biochem. Funct., 22: 343–352. doi: 10.1002/cbf.1149
- Issue published online: 26 OCT 2004
- Article first published online: 11 AUG 2004
- Manuscript Accepted: 22 JAN 2004
- Manuscript Revised: 7 JAN 2004
- Manuscript Received: 9 OCT 2003
- Beckman Research Institute of the City of Hope
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It instils several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. It is crucial in the removal and detoxification of carcinogens, and alterations in this pathway, can have a profound effect on cell survival. However, by conferring resistance to a number of chemotherapeutic drugs, elevated levels of glutathione in tumour cells are able to protect such cells in bone marrow, breast, colon, larynx and lung cancers. Here we present a number of studies investigating the role of glutathione in promoting cancer, impeding chemotherapy, and the use of glutathione modulation to enhance anti-neoplastic therapy. Copyright © 2004 John Wiley & Sons, Ltd.