Vascular redox imbalance in rats submitted to chronic exercise

Authors

  • Ricardo Fagundes da Rocha,

    Corresponding author
    1. Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Institute of Health Basic Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
    Current affiliation:
    1. Rua Ramiro Barcelos, número 2600, prédio Anexo, bairro Santa Cecília, CEP 90035-003, Porto Alegre, Rio Grande do Sul, Brazil.
    • Laboratório 32, Departamento de Bioquímica Professor Tuiskon Dick, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFGRS), Brazil.
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  • Marcos Roberto de Oliveira,

    1. Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Institute of Health Basic Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
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  • Matheus Augusto de Bittencourt Pasquali,

    1. Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Institute of Health Basic Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
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  • Michael Éverton Andrades,

    1. Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Institute of Health Basic Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
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  • Max William Soares Oliveira,

    1. Faculty of Health, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia
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  • Guilherme Antônio Behr,

    1. Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Institute of Health Basic Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
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  • José Cláudio Fonseca Moreira

    1. Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Institute of Health Basic Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
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Abstract

Exercise training has been used for treatment/prevention of many cardiovascular diseases, but the mechanisms need to be clarified. Thus, our aim was to compare oxidative stress parameters between rats submitted to a swimming training and sedentary rats (control). Twelve male rats were divided into two groups: control and exercise training. The exercise training had daily 1 h swimming sessions for 8 weeks and a load (5% of its body mass) was placed in rat's tail. Thereafter the animals were killed, aorta and heart were surgically removed and blood was collected. Body mass gain, thiobarbituric acid reactive species (TBARS), carbonyl content, total reactive antioxidant potential (TRAP), total antioxidant reactivity (TAR), superoxide dismutase (SOD) activity and catalase (CAT) activity were evaluted. The trained rats showed a lower body mass gain and no modifications on heart. An increased SOD activity was observed on aorta after the training, but no changes were seen for CAT activity, which led to an increased SOD/CAT ratio. The arterial TBARS was also increased for trained rats. The decrease in TRAP in exercise training was the single modification on plasma. Our findings suggest that the increased SOD activity could play a role in vascular adaptations to exercise training. Copyright © 2010 John Wiley & Sons, Ltd.

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