P-bodies and their functions during mRNA cell cycle: Mini-review
Version of Record online: 17 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Cell Biochemistry and Function
Volume 30, Issue 3, pages 177–182, April 2012
How to Cite
Olszewska, M., Bujarski, J. J. and Kurpisz, M. (2012), P-bodies and their functions during mRNA cell cycle: Mini-review. Cell Biochem. Funct., 30: 177–182. doi: 10.1002/cbf.2804
- Issue online: 4 APR 2012
- Version of Record online: 17 JAN 2012
- Manuscript Accepted: 16 DEC 2011
- Manuscript Revised: 6 DEC 2011
- Manuscript Received: 17 MAY 2011
- stress granules;
- mRNA cell cycle
P-bodies (processing bodies) are observed in different organisms such as yeast, Caenorhabditis elegans and mammals. A typical eukaryotic cell contains several types of spatially formed granules, such as P-bodies, stress granules and a variety of ribonucleoprotein bodies. These microdomains play important role in mRNA processing, including RNA interference, repression of translation and mRNA decay. The P-bodies components as well as stress granules may play an important role in host defense against viral infection. The complete set of P-bodies protein elements is still poor known. They contain conserved protein core limited to different organisms or to stress status of the cell. P-bodies are related also to some neuronal mRNA granules as well as to maternal RNA granules or male germ cell granules. In this mini-review, we focus on the structure of P-bodies and their function in the mRNA utilization and processing because of the high mRNA's dynamics between different cellular compartments and its key role in modulation of gene expression. Copyright © 2012 John Wiley & Sons, Ltd.