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Short sleep duration and obesity: mechanisms and future perspectives

Authors

  • Ioná Zalcman Zimberg,

    1. Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil
    2. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
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  • Ana Dâmaso,

    1. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
    2. Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil
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  • Mariana Del Re,

    1. Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil
    2. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
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  • Aline Millani Carneiro,

    1. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
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  • Helton de Sá Souza,

    1. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
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  • Fábio Santos de Lira,

    1. Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil
    2. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
    3. Laboratório de Fisiologia e Bioquímica do Exercício, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
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  • Sergio Tufik,

    1. Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil
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  • Marco Túlio de Mello

    Corresponding author
    1. Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil
    • Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil
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M. T. de Mello, Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Professor Francisco de Castro, 93. Vila Clementino, São Paulo, SP, Brazil, CEP 04020–050.

E-mail: tmello@demello.net.br

Abstract

A reduction of sleep time has become common over the last century, and growing evidence from both epidemiological and laboratory-based studies suggests sleep curtailment is a new risk factor for the development of obesity. On this basis, the present review examines the role of sleep curtailment in the metabolic and endocrine alterations, including decreased glucose tolerance and insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. It will be discussed how sleep restriction may lead to increase in food intake and result in greater fatigue, which may favour decreased energy expenditure. Altogether, evidences point to a possible role of decreased sleep duration in the current epidemic of obesity and therefore present literature highlights the importance of getting enough good sleep for metabolic health. Many aspects still need to be clarified and intervention studies also need to be conducted. Copyright © 2012 John Wiley & Sons, Ltd.

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