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Development of a Lectin Microarray for the Rapid Analysis of Protein Glycopatterns

Authors

  • Kanoelani T. Pilobello,

    1. Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712-0265, USA
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  • Lakshmipriya Krishnamoorthy,

    1. Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712-0265, USA
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  • Deepika Slawek,

    1. Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712-0265, USA
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  • Lara K. Mahal Dr.

    1. Department of Chemistry and Biochemistry and the Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712-0265, USA, Fax: (+1) 512-471-8696
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Abstract

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Glycosylation plays a role in a wide variety of biological processes including bacterial pathogenesis, tumor cell metastasis and inflammation. Despite the importance of carbohydrates, few techniques exist for the rapid and systematic evaluation of protein glycosylation. This paper describes a lectin microarray for the rapid analysis of protein glycopatterns (see scheme).

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