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Pseudo 3D Single-Walled Carbon Nanotube Film for BSA-Free Protein Chips

Authors

  • Hye Ryung Byon,

    1. Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-Dong, Nam-Gu, Pohang, 790-784, Korea, Fax: (+82) 5-279-3399
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  • Bong Jin Hong Dr.,

    1. Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-Dong, Nam-Gu, Pohang, 790-784, Korea, Fax: (+82) 5-279-3399
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  • Yong Song Gho Prof.,

    1. Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja-dong, Nam-Gu, Pohang, 790-784, Korea
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  • Joon Won Park Prof.,

    1. Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-Dong, Nam-Gu, Pohang, 790-784, Korea, Fax: (+82) 5-279-3399
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  • Hee Cheul Choi Prof.

    1. Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-Dong, Nam-Gu, Pohang, 790-784, Korea, Fax: (+82) 5-279-3399
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Abstract

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Sweet home for proteins. Single-walled carbon nanotube (SWNT) film treated with CDI–Tween20 (CT) has been used as a substrate for a BSA-free protein chip. In the absence of BSA, which is conventionally applied as a nonspecific binding inhibitor, protein A, biotinylated BSA, and even small peptide such as 3×FLAG immobilized on the CT-functionalized SWNT film substrates recognize their respective counterparts, streptavidin, immunoglobulin G, and antiFLAG. with high specificity.

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