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Keywords:

  • amyloid fibrils;
  • catalase;
  • inhibitors;
  • proteins;
  • thioflavin T
Thumbnail image of graphical abstract

Molecular coatings on biological surfaces. Small molecules that bind to and coat Alzheimer's related β-amyloid fibrils can function as inhibitors of the interaction of amyloid-binding proteins with these fibrils. Derivatives of thioflavin T are shown to inhibit the binding of a monoclonal anti-Aβ IgG, human catalase, and recombinant human ABAD to in vitro-grown amyloid fibrils.