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Keywords:

  • anthracyclines;
  • aranciamycin;
  • biosynthesis;
  • gene clusters;
  • transferases
Thumbnail image of graphical abstract

Add sugar… Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase, AraGT, which accepts different nucleotide-activated sugars (D-amicetose, L-rhodinose, L-rhamnose and L-axenose) The newly generated aranciamycin derivatives displayed antiproliferative activity against MaTu and MCF7 cells; this shows that the deoxysugar is important for anticancer activity.