Communication

Inhibition of Biochemical Reactions by Silicon Nanowires through Modulating Enzyme Activities

  1. Changqing Yi1,
  2. Chi-Chun Fong Dr.1,
  3. Weiwei Chen Dr.2,
  4. Suijian Qi1,
  5. Shuit-Tong Lee Prof. Dr.2,
  6. Mengsu Yang Prof. Dr.1

Article first published online: 13 JUN 2007

DOI: 10.1002/cbic.200700136

Issue

ChemBioChem

ChemBioChem

Volume 8, Issue 11, pages 1225–1229, July 23, 2007

Additional Information

How to Cite

Yi, C., Fong, C.-C., Chen, W., Qi, S., Lee, S.-T. and Yang, M. (2007), Inhibition of Biochemical Reactions by Silicon Nanowires through Modulating Enzyme Activities. ChemBioChem, 8: 1225–1229. doi: 10.1002/cbic.200700136

Author Information

  1. 1

    Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, China, Fax: (+852) 2788-7406

  2. 2

    Center of Super-Diamond and Advanced Films and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, China, Fax: (+852) 2784-4696

Publication History

  1. Issue published online: 10 JUL 2007
  2. Article first published online: 13 JUN 2007
  3. Manuscript Received: 21 MAR 2007

Funded by

  • Research Grants Council of Hong Kong, SAR, China. Grant Number: CityU 3/04C

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Keywords:

  • DNA;
  • enzymes;
  • nanostructures;
  • polymerase chain reaction
Thumbnail image of graphical abstract

Through the wire. We have investigated the potential effects of silicon nanowires (SiNW-SiO2) and SiNWs functionalized with carboxylic groups (SiNW-COOH) on restriction endonucleases and Taq DNA polymerase. The results show that these SiNWs can inhibit enzyme activity (lower band in gel). Our findings suggest that this could be due to chemical interactions between the functional groups on SiNWs and the enzymes.

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