Communication

Molecular Effects of Uptake of Gold Nanoparticles in HeLa Cells

  1. Jameel Ahmad Khan1,
  2. Beena Pillai Dr.1,
  3. Taposh Kumar Das Dr.2,
  4. Yogendra Singh Dr.1,
  5. Souvik Maiti Dr.1

Article first published online: 14 JUN 2007

DOI: 10.1002/cbic.200700165

Issue

ChemBioChem

ChemBioChem

Volume 8, Issue 11, pages 1237–1240, July 23, 2007

Additional Information

How to Cite

Khan, J. A., Pillai, B., Das, T. K., Singh, Y. and Maiti, S. (2007), Molecular Effects of Uptake of Gold Nanoparticles in HeLa Cells. ChemBioChem, 8: 1237–1240. doi: 10.1002/cbic.200700165

Author Information

  1. 1

    Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India, Fax: (+91)11-27667471

  2. 2

    All India Institute of Medical Sciences, Ansari, New Delhi 110 029, India

Publication History

  1. Issue published online: 10 JUL 2007
  2. Article first published online: 14 JUN 2007
  3. Manuscript Received: 3 APR 2007

Funded by

  • CSIR, Government of India
  • University Grants Commission, New Delhi, India

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Keywords:

  • cytotoxicity;
  • gene expression;
  • microarrays;
  • nanostructures;
  • toxicogenomics
Thumbnail image of graphical abstract

Mellow gold. Toxicogenomics of nanoparticles can expose subtle yet clinically relevant alterations in the intracellular environment that arise from downstream effects of nanoparticle accumulation inside cells. Genome-wide expression profiling by using DNA microarrays revealed that internalization of gold nanoparticles is not associated with gross changes in transcription in HeLa cells (see figure).

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