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Keywords:

  • DNA replication;
  • genotyping;
  • microarrays;
  • oligonucleotides;
  • single nucleotide polymorphism
Thumbnail image of graphical abstract

Mutant detects mutation. A mutant DNA polymerase, which was derived from Pyrococcus furiosus DNA polymerase (M2 in figure), was found to have improved single-nucleotide discrimination properties, and was used for selective microarrayed-primer extensions. This approach allowed multiplexed SNP detection.