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Keywords:

  • Alzheimer's disease;
  • circular dichroism;
  • dehydrophenylalanine;
  • protein structures;
  • trifluoroethanol
Thumbnail image of graphical abstract

Breaking the sheets: Crystallography studies illustrated the potential of α,β-dehydrophenylalanine (ΔPhe) to interrupt the propagation of an extended structure in the de novo designed pentapeptide 1. To further explore the role of ΔPhe as a β-breaker residue, it was incorporated into the 16–20 segment of the Aβ1–40 sequence. TEM studies suggest that ΔPhe might be useful as a β breaker in peptide-based antifibrillizing drugs.