Photocontrol of Genomic DNA Conformation by Using a Photosensitive Gemini Surfactant: Binding Affinity versus Reversibility

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Abstract

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Precious GEM: In this communication, we demonstrate that a photosensitive gemini surfactant (AzoGEM) can be used to control the conformation of individual genomic DNA molecules at a surfactant-to-DNA charge ratio near to unity, which is 1000 times smaller than that for the systems reported to date (AzoTAB). We analyze the AzoGEM–DNA and AzoTAB–DNA interactions in terms of binding affinity and reversibility.

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