Achieving Turnover in DNA-Templated Reactions



original image

Quasi-intramolecular: Templates bind reactants and increase the effective molarity of their reactive groups. This results in the acceleration of the templated reactions. Programmable self-recognition properties make nucleic acids particularly well adapted to templated synthesis, and have resulted in applications in DNA and RNA detection, prodrug activation and asymmetric catalysis. This minireview aims to summarise the current state of templated reactions catalysed by DNA and RNA.