Communication

S-Adenosyl-L-Methionine Hydrolase (Adenosine-Forming), a Conserved Bacterial and Archeal Protein Related to SAM-Dependent Halogenases

  1. Alessandra S. Eustáquio Dr.1,
  2. Johannes Härle1,
  3. Joseph P. Noel Prof. Dr.2,
  4. Bradley S. Moore Prof. Dr.1

Article first published online: 21 AUG 2008

DOI: 10.1002/cbic.200800341

Issue

ChemBioChem

ChemBioChem

Volume 9, Issue 14, pages 2215–2219, September 22, 2008

Additional Information

How to Cite

Eustáquio, A. S., Härle, J., Noel, J. P. and Moore, B. S. (2008), S-Adenosyl-L-Methionine Hydrolase (Adenosine-Forming), a Conserved Bacterial and Archeal Protein Related to SAM-Dependent Halogenases. ChemBioChem, 9: 2215–2219. doi: 10.1002/cbic.200800341

Author Information

  1. 1

    Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0204 (USA), Fax: (+1) 1-858-534-1305

  2. 2

    Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 (USA)

Publication History

  1. Issue published online: 17 SEP 2008
  2. Article first published online: 21 AUG 2008
  3. Manuscript Received: 22 MAY 2008

Funded by

  • NIH. Grant Number: CA127622
  • National Science Foundation. Grant Number: MCB-023602

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Keywords:

  • DUF62;
  • halogenation;
  • hydrolase;
  • S-adenosyl-L-methionine;
  • Salinispora

Graphical Abstract

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Halogenase versus hydrolase: The newly discovered SAM-dependent halogenases belong to a family of over 100 proteins from bacteria and archaea. Biochemical and in silico analyses reported here suggest, however, that most of these relatives act as previously unknown SAM adenosylhydrolases rather than halogenases.

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