SEARCH

SEARCH BY CITATION

Keywords:

  • Antisense agents;
  • caged compounds;
  • DNA;
  • gene regulation;
  • RNA
Thumbnail image of graphical abstract

On and off the spot: The spatio-temporal light-activation of gene silencing was achieved through the complete inactivation of phosphorothioate antisense agents by installing light-removable (caged) groups at specific sites, as illustrated here. Full antisense activity was restored through a brief irradiation with UV light at 365 nm.