Communication

Investigation of Tailoring Modifications in Pradimicin Biosynthesis

  1. Jixun Zhan Prof. Dr.1,2,
  2. Kangjian Qiao1,
  3. Yi Tang Prof.1

Article first published online: 8 MAY 2009

DOI: 10.1002/cbic.200900082

Issue

ChemBioChem

ChemBioChem

Volume 10, Issue 9, pages 1447–1452, June 15, 2009

Additional Information

How to Cite

Zhan, J., Qiao, K. and Tang, Y. (2009), Investigation of Tailoring Modifications in Pradimicin Biosynthesis. ChemBioChem, 10: 1447–1452. doi: 10.1002/cbic.200900082

Author Information

  1. 1

    Department of Chemical and Biomolecular Engineering, University of California, 420 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-4107

  2. 2

    Current address: Department of Biological and Irrigation Engineering, Utah State University, 4105 Old Main Hill, Logan, UT 84322 (USA)

Publication History

  1. Issue published online: 9 JUN 2009
  2. Article first published online: 8 MAY 2009
  3. Manuscript Received: 14 FEB 2009

Funded by

  • University-wide AIDS Research Program
  • University of California. Grant Number: ID06-LA-193
  • National Science Foundation. Grant Number: CBET 0545860

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Keywords:

  • amino acids;
  • biosynthesis;
  • metabolism;
  • P450 hydroxylase;
  • polyketides

Abstract

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Decorating pradimicin: Three tailoring enzymes in the pradimicin biosynthetic pathway have been investigated. PdmN and PdmJ were identified as a D-amino acid ligase and a C-5 P450 hydroxylase, respectively, whereas PdmW was deduced to be the C-6 P450 hydroxylase.

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