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Complex Oxidation Chemistry in the Biosynthetic Pathways to Vancomycin/Teicoplanin Antibiotics
Article first published online: 16 JUN 2009
DOI: 10.1002/cbic.200900117
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Widboom, P. F. and Bruner, S. D. (2009), Complex Oxidation Chemistry in the Biosynthetic Pathways to Vancomycin/Teicoplanin Antibiotics. ChemBioChem, 10: 1757–1764. doi: 10.1002/cbic.200900117
Publication History
- Issue published online: 13 JUL 2009
- Article first published online: 16 JUN 2009
- Manuscript Received: 5 MAR 2009
- Abstract
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Keywords:
- amino acids;
- antibiotics;
- biosynthesis;
- natural products;
- nonribosomal peptide synthetases
Graphical Abstract
O2can do: Investigations into the machinery responsible for the biosynthesis of the vancomycin/teicoplanin family of antibiotics have uncovered multiple examples of novel enzyme chemistry. In particular, oxidation chemistry plays key roles in constructing the complex structures of the natural products. From biosynthesis of rare amino acids to the tailoring of the peptide product, diverse enzyme-catalyzed reactions are discussed with a focus on structure and chemical mechanism.