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Communication
GilR, an Unusual Lactone-Forming Enzyme Involved in Gilvocarcin Biosynthesis
Article first published online: 22 APR 2009
DOI: 10.1002/cbic.200900130
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Kharel, M. K., Pahari, P., Lian, H. and Rohr, J. (2009), GilR, an Unusual Lactone-Forming Enzyme Involved in Gilvocarcin Biosynthesis. ChemBioChem, 10: 1305–1308. doi: 10.1002/cbic.200900130
Publication History
- Issue published online: 14 MAY 2009
- Article first published online: 22 APR 2009
- Manuscript Received: 10 MAR 2009
Funded by
- US National Institute of Health. Grant Number: CA 102102
Corrigendum: Corrigendum: GilR, an Unusual Lactone-Forming Enzyme Involved in Gilvocarcin Biosynthesis
Vol. 11, Issue 9, 1161, Article first published online: 7 JUN 2010
Keywords:
- biosynthesis;
- C-glycosides;
- dehydrogenases;
- gilvocarcins;
- lactones
Abstract
Last at last: The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.