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Keywords:

  • cell adhesion;
  • cell patterning;
  • dynamic surface;
  • electrochemistry;
  • monolayers;
  • photoactivation

Abstract

Thumbnail image of graphical abstract

Coculture control: We report a combined photochemical and electroactive self-assembled monolayer (SAM)-based substrate strategy to generate a coculture platform with spatial and temporal control of cell–cell interactions. These dynamic substrates can present a variety of ligands on the surface for biospecific interactions between the ligands and cell surface receptors. Photopatterning enables the ligands to be immobilized in patterns and even gradients.