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Keywords:

  • antibiotics;
  • biosynthesis;
  • condensation;
  • shikimate;
  • virulence factors
Thumbnail image of graphical abstract

Five easy steps: Phenazines are redox-active bacterial secondary metabolites that possess broad-specificity antibiotic activity and can also play an important role as virulence factors in infectious disease. Their biosynthesis from two molecules of chorismic acid is catalyzed by enzymes encoded in the conserved phz operon.