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Keywords:

  • aggregation;
  • amyloid fibrils;
  • asparagine;
  • glutamine;
  • misfolding;
  • prions
Thumbnail image of graphical abstract

Build up? The availability of fully sequenced genomes provides a useful starting point for identifying putative amyloid- and prion-forming sequences through genome-wide scans. With an inventory in hand, one can assess the amyloid-forming potential and the functional consequences of amyloid formation for each sequence, thus advancing our understanding of how cells process and utilize deleterious and functional aggregates, respectively.