Communication

Artificial Protein Block Copolymers Blocks Comprising Two Distinct Self-Assembling Domains

  1. Jennifer S. Haghpanah1,
  2. Carlo Yuvienco1,
  3. Deniz E. Civay2,
  4. Hanna Barra1,
  5. Peter J. Baker1,
  6. Sachin Khapli Dr.1,
  7. Natalya Voloshchuk Dr.1,
  8. Susheel K. Gunasekar1,
  9. Murugappan Muthukumar Prof.2,
  10. Jin K. Montclare Prof.1,3

Article first published online: 5 OCT 2009

DOI: 10.1002/cbic.200900539

Issue

ChemBioChem

ChemBioChem

Volume 10, Issue 17, pages 2733–2735, November 23, 2009

Additional Information

How to Cite

Haghpanah, J. S., Yuvienco, C., Civay, D. E., Barra, H., Baker, P. J., Khapli, S., Voloshchuk, N., Gunasekar, S. K., Muthukumar, M. and Montclare, J. K. (2009), Artificial Protein Block Copolymers Blocks Comprising Two Distinct Self-Assembling Domains. ChemBioChem, 10: 2733–2735. doi: 10.1002/cbic.200900539

Author Information

  1. 1

    Department of Chemical and Biological Sciences, Polytechnic Institute of NYU, 6 Metrotech Center, Brooklyn, NY 11201 (USA), Fax: (+1) 718-260-3676

  2. 2

    Polymer Science and Engineering Department, University of Massachusetts–Amherst, 120 Governors Drive, Amherst, MA 01003 (USA), Fax: (+1) 413-545-0082

  3. 3

    Department of Biochemistry, SUNY Downstate Medical Center, Brooklyn, NY 11203 (USA)

Publication History

  1. Issue published online: 17 NOV 2009
  2. Article first published online: 5 OCT 2009
  3. Manuscript Received: 27 AUG 2009

Funded by

  • AFOSR. Grant Numbers: FA-9550-07-1-0060, FA9550-07-1-0347
  • NSF MRSEC. Grant Numbers: DMR-0820341, DMR-0706454
  • GK-12 Fellows. Grant Number: DGE-0741714

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Keywords:

  • alpha-helices;
  • biomaterials;
  • elastin;
  • protein structures;
  • self-assembly
Thumbnail image of graphical abstract

It's the way that you do it: Block polymers composed of elastin (E) and COMPcc (C) domains (see figure) have been synthesised and characterised. The protein motifs were chosen for their structures and distinct self-assembly modes. We demonstrate that the micro- and macrostructures of the polymers are dictated by the orientation of the fusions and the number of repeated blocks.

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