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Keywords:

  • antibiotics;
  • biosynthesis;
  • conditionally essential enzymes;
  • Gram-positive bacteria;
  • wall teichoic acid (WTA)
Thumbnail image of graphical abstract

Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram-positive bacteria. WTAs have profound effects on the physiology of Gram-positive organisms, and impact everything from cation homeostasis to antibiotic susceptibility to survival in a host. This review summarizes recent advances made toward understanding WTA function, biosynthesis and inhibition.