Wall Teichoic Acid Function, Biosynthesis, and Inhibition

Authors

  • Jonathan G. Swoboda Dr.,

    1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Armenise 633, Boston, MA 02115 (USA), Fax: (+1) 617-738-7664
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  • Jennifer Campbell Dr.,

    1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Armenise 633, Boston, MA 02115 (USA), Fax: (+1) 617-738-7664
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  • Timothy C. Meredith Dr.,

    1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Armenise 633, Boston, MA 02115 (USA), Fax: (+1) 617-738-7664
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  • Suzanne Walker Prof.

    1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Armenise 633, Boston, MA 02115 (USA), Fax: (+1) 617-738-7664
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Abstract

original image

Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram-positive bacteria. WTAs have profound effects on the physiology of Gram-positive organisms, and impact everything from cation homeostasis to antibiotic susceptibility to survival in a host. This review summarizes recent advances made toward understanding WTA function, biosynthesis and inhibition.

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