Minireview

Understanding and Exploiting Protein Prenyltransferases

  1. Uyen T. T. Nguyen Dr.1,2,
  2. Roger S. Goody Prof. Dr.2,
  3. Kirill Alexandrov Prof. Dr.3

Article first published online: 29 APR 2010

DOI: 10.1002/cbic.200900727

Issue

ChemBioChem

ChemBioChem

Volume 11, Issue 9, pages 1194–1201, June 14, 2010

Additional Information

How to Cite

Nguyen, U. T. T., Goody, R. S. and Alexandrov, K. (2010), Understanding and Exploiting Protein Prenyltransferases. ChemBioChem, 11: 1194–1201. doi: 10.1002/cbic.200900727

Author Information

  1. 1

    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10065 (USA)

  2. 2

    Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)

  3. 3

    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, 4072 (Australia), Fax: (+61) 7-3346-2101

Publication History

  1. Issue published online: 7 JUN 2010
  2. Article first published online: 29 APR 2010
  3. Manuscript Received: 1 DEC 2009

Funded by

  • NHMRC. Grant Number: 569652

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (539K)

Keywords:

  • antitumor agents;
  • GTPases;
  • isoprenoids;
  • protein modifications;
  • protein prenylation
Thumbnail image of graphical abstract

Lipidating proteins: Protein prenylation is catalyzed by protein prenyltransferases, and enables proteins to reversibly associate with intracellular membranes. The mechanisms of protein prenylation and the recent developments in analysis and biotechnological exploitation of these modifications are reviewed.

View Full Article (HTML) Get PDF (539K)