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Keywords:

  • ligation;
  • peptide O-esters;
  • peptide thioesters;
  • peptides;
  • solid-phase synthesis
Thumbnail image of graphical abstract

Designer peptides: A large reactivity difference was observed between two peptide O-esters that can undergo peptide ligation through an in situ O-to-S acyl shift. This observation allowed for the design of “one-pot” N-to-C sequential peptide fragment condensation through kinetically controlled ligation with more readily accessible peptide O-esters.