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Vitamin B6 Biosynthesis: Charting the Mechanistic Landscape

  1. Teresa B. Fitzpatrick Prof.,
  2. Cyril Moccand,
  3. Céline Roux Dr.

Article first published online: 15 APR 2010

DOI: 10.1002/cbic.201000084

Issue

ChemBioChem

ChemBioChem

Volume 11, Issue 9, pages 1185–1193, June 14, 2010

Additional Information

How to Cite

Fitzpatrick, T. B., Moccand, C. and Roux, C. (2010), Vitamin B6 Biosynthesis: Charting the Mechanistic Landscape. ChemBioChem, 11: 1185–1193. doi: 10.1002/cbic.201000084

Author Information

  1. Department of Botany and Plant Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneva 4 (Switzerland)

Publication History

  1. Issue published online: 7 JUN 2010
  2. Article first published online: 15 APR 2010
  3. Manuscript Received: 11 FEB 2010

Funded by

  • Swiss National Science Foundation. Grant Number: PPOOA_119186

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Keywords:

  • (beta/alpha)8 barrel;
  • ammonia tunnel;
  • reaction mechanisms;
  • vitamin B6;
  • vitamins
Thumbnail image of graphical abstract

Enzyme of the rings: Vitamin B6 biosynthesis through the DXP-independent route is catalyzed by PLP synthase. The enzyme utilizes ribose 5-phosphate, glyceraldehyde 3-phosphate and ammonia to synthesize the cofactor form of the vitamin, pyridoxal 5′-phosphate (PLP). This review provides the emerging mechanistic details of this remarkable Pdx1:Pdx2 glutamine amidotransferase complex.

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