Communication

Synthesis of a High-Purity Chemical Library Reveals a Potent Inducer of Oxidative Stress

  1. Jiayue Cui1,
  2. Kenji Matsumoto1,
  3. Cindy Y. Wang2,
  4. Marcus E. Peter Prof.2,
  5. Sergey A. Kozmin Prof.1

Article first published online: 11 MAY 2010

DOI: 10.1002/cbic.201000193

Issue

ChemBioChem

ChemBioChem

Volume 11, Issue 9, pages 1224–1227, June 14, 2010

Additional Information

How to Cite

Cui, J., Matsumoto, K., Wang, C. Y., Peter, M. E. and Kozmin, S. A. (2010), Synthesis of a High-Purity Chemical Library Reveals a Potent Inducer of Oxidative Stress. ChemBioChem, 11: 1224–1227. doi: 10.1002/cbic.201000193

Author Information

  1. 1

    Department of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637 (USA), Fax: (+1) 773-702-0805

  2. 2

    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637 (USA)

Publication History

  1. Issue published online: 7 JUN 2010
  2. Article first published online: 11 MAY 2010
  3. Manuscript Received: 26 MAR 2010

Funded by

  • NIH. Grant Number: P50 GM086145
  • Sloan Foundation
  • Dreyfus Foundation
  • Amgen
  • GSK

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Keywords:

  • apoptosis;
  • caspases;
  • chemical libraries;
  • cytotoxicity;
  • reactive oxygen species
Thumbnail image of graphical abstract

Needle in a haystack: Synthesis of a high-purity, biogenic, heterocyclic, 936-member library enabled the identification of a small molecule, triazatricyclamide (1), that potently inhibited the proliferation of several cancer cell lines and induced rapid oxidative stress. Unusually, this agent caused cell death by activating both caspase-dependent and -independent pathways.

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